Asymmetric total synthesis of (+)-merobatzelladine B.

Polycyclic guanidine natural products, such as batzelladines A, E, and F, exhibit a rich and diverse array of interesting biological activities (Figure 1). Some polycyclic guanidine alkaloids have been shown to inhibit protein–protein interactions, including the binding of HIV gp120 to CD4 on human T-cells. Furthermore, many polycyclic guanidines display potent antiviral, antimalarial, and immunosuppressive properties.